3D Bioprinting for in vitro Tissue Models

Author: Wei Sun

3D Bio-Printing uses cells and biomaterials as building blocks to fabricate personalized 3D structures or functional in vitro biological models. The technology has been widely applied to regenerative medicine, disease study and drug discovery. This presentation will report our recent research on printing cells for construction of micro-organ chips and for building in vitro 3D tumor models.  An overview of advances of 3D Bio-Printing will be given. Enabling methods for cell printing will be described. Examples for 3D Printing of tissue engineering model, drug metabolism model and disease model will be reported, along with results of printing parameters on cell viability and 3D tumor structural formation, characterization of cell morphologies, proliferations, protein expressions and chemoresistances. Comparison of biological data derived from 3D printed models with 2D planar petri-dishes models will be conducted. Discussions on challenges and opportunities of 3D Bio-Printing will also be presented.